四川大學(xué)生命科學(xué)學(xué)院導(dǎo)師：王亞軍 正文

　　
　　姓名：王亞軍　性別：男
　　職稱：教授　學(xué)院：生命科學(xué)學(xué)院
　　聯(lián)系方式：
　　辦公室電話：028-85415025
　　電子郵件：cdwyjhk@gmail.com
　　
　　學(xué)習(xí)與工作簡(jiǎn)歷：
　　1987-1991: 西南師范大學(xué)生物系，理學(xué)學(xué)士。
　　1991-1994: 四川大學(xué)生物系，理學(xué)碩士。
　　1994-1999: 四川大學(xué)生物系 助教、講師。
　　1999-2003: 香港中文大學(xué)(The Chinese University of Hong Kong) 博士。
　　2003-2004: 香港中文大學(xué)（The Chinese University of Hong Kong）博士后。
　　2004-2007: 香港大學(xué) (The University of Hong Kong), 博士后。
　　2007-現(xiàn)在： 四川大學(xué)生命科學(xué)學(xué)院 。

　　個(gè)人研究簡(jiǎn)介：
　　斑馬魚作為模式生物一直在發(fā)育生物學(xué)、比較內(nèi)分泌學(xué)等領(lǐng)域扮演重要角色。王亞軍博士在香港中文大學(xué)博士攻讀期間（1999-2003），以斑馬魚為研究模型，探究卵巢產(chǎn)生的一些生長(zhǎng)因子，包括激活素（Activins）及其結(jié)合蛋白(Follistatin)，表皮生長(zhǎng)因子（EGF）及其受體（EGFR），以及PACAP及其受體在控制卵泡發(fā)育與類固醇激素生成中的作用。 二零零四年，王亞軍博士加入香港大學(xué)理學(xué)院長(zhǎng)梁志清教授實(shí)驗(yàn)室從事博士后研究。以家雞為研究模型，圍繞神經(jīng)內(nèi)分泌生長(zhǎng)軸（調(diào)節(jié)生長(zhǎng)發(fā)育的主要途徑）,致力于基因功能鑒定以及基因網(wǎng)絡(luò)調(diào)控解析，并首次在家雞等非哺乳類脊椎動(dòng)物中鑒定到生長(zhǎng)激素釋放激素 (GHRH)及其兩個(gè)專一性受體(GHRHR1 , GHRHR2)基因。 王亞軍博士的系列研究結(jié)果已先后發(fā)表在<Endocrinology>, <Biology of Reproduction>, <PNAS>等領(lǐng)域內(nèi)著名刊物上。 回到四川大學(xué)后，王亞軍博士在四川大學(xué)引進(jìn)人才基金支持下，組建畜禽功能基因研究平臺(tái)，主以家雞、斑馬魚為模型探究： 1) 神經(jīng)多肽 (如:GHRH, PrRP, GCG2等)、神經(jīng)遞質(zhì)、生長(zhǎng)因子等對(duì)垂體功能的調(diào)節(jié)及其胞內(nèi)信號(hào)傳導(dǎo)機(jī)制；2) 基因功能及其表達(dá)調(diào)控; 3) 經(jīng)濟(jì)動(dòng)物重要性狀形成分子基礎(chǔ)；4) 動(dòng)物生長(zhǎng)與代謝調(diào)節(jié)機(jī)制。
　　
　　研究方向：
　　動(dòng)物細(xì)胞生物學(xué)、繁殖生物學(xué)、比較內(nèi)分泌學(xué)
　　
　　項(xiàng)目支持：
　　國(guó)家自然科學(xué)基金、轉(zhuǎn)基因生物新品種培育重大專項(xiàng)、國(guó)家高技術(shù)研究發(fā)展計(jì)劃.

　　代表性論文：
　　1. Wang Y*, Wang CY, Wu Y, et al. Identification of the Receptors for Prolactin-releasing Peptide (PrRP) and Carassius RFamide Peptide (C-RFa) in Chickens. Endocrinology, 153: p1-14, 2012 (online) (*通訊作者) (IF=4.993).
　　
　　2. Wang Y*, Huang G, Li J., et al., Characterization of Chicken Secretin (SCT) and Secretin Receptor (SCTR) Genes: A Novel Secretin-like Peptide (SCT-LP) and Secretin Encoded in a Single Gene. Molecular and Cellular Endocrinology, 348: 270-280, 2012 (*通迅作者) (IF=4.118).
　　
　　3. Huang G, Li J, Fu H, Yan Z, Bu G, He X, Wang Y* Characterization of glucagon-like peptide 1 receptor (GLP1R) gene in chickens: functional analysis, tissue distribution, and identification of its transcript variants. Domestic Animal Endocrinology (online), p1-15, 2012 (* 通迅作者) (IF= 1.896)
　　
　　4. Ho JC, Kwok AH, Zhao D, Wang Y*, et al. Characterization of the chicken galanin type I receptor (GalR1) and a novel GalR1-like receptor (GalR1-L). General and Comparative Endocrinology 170: 391-400, 2011 (*通訊作者) (IF=3.108).
　　
　　5. Ruiqiang Li, Wei Fan, Geng Tian, Hongmei Zhu, Lin He, ……, Yajun Wang*… Lars Bolund, Karsten Kristiansen, Gane Ka-Shu Wong, Maynard Olson, Xiuqing Zhang, Songgang Li, Huanming Yang, Jian Wang & Jun Wang. The sequence and de novo assembly of the giant panda genome. Nature, 463: 311-317, 2010 (IF=36.101)
　　
　　6. Wang Y*, Li J, Kwok AHY, et al., A novel prolactin-like protein (PRL-L) gene in chickens and zebrafish: Cloning and Characterization of its tissue expression. General and Comparative endocrinology 166: 200-210, 2010. (IF=3.108)
　　
　　7. Wang Y*, Li J, C. Wang CY, et al., Characterization of the receptors for chicken GHRH and GHRH-related peptides: Identification of a novel receptor for GHRH and the receptor for GHRH-LP (PRP). Domestic Animal Endocrinology 38: 13-31, 2010 (IF=1.896).
　　
　　8. Lynch VJ，Tanzer A, Wang Y*, et al., Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals. Proc. Natl. Acad. Sci. U S A. 105: 14925-14933, 2008. (IF=9.598)
9. Wang J, Wang Y*, Li X, et al., Cloning, tissues distribution and functional characterization of chicken glucagon receptor. Poultry science 87: 2678-2688, 2008 (IF=1.603)
　　
　　10. Kwok AHY, Wang Y*, Wang CY, et al., Molecular cloning and characterization of chicken prostaglandin E receptor subtypes 2 and 4 (EP2 and EP4) General and Comparative Endocrinology, 157: 99-106, 2008 (IF=3.108)
11. Wang Y*, Li J, Wang CY, et al., Identification of the endogenous ligands for chicken growth hormone-releasing hormone (GHRH) receptor. Evidence for a separate gene encoding GHRH in submammalian vertebrates. Endocrinology 148: 2405-2416, 2007. (IF=5.045)
　　
　　12. Wang Y*, Li J，Wang CY, et al., Epidermal growth factor receptor (EGFR) ligand in the chicken ovary: I) Evidence for heparin binding epidermal growth factor-like growth factor (HB-EGF) as a potential oocyte-derived factor to control granulosa cell proliferation and HB-EGF and Kit ligand expression. Endocrinology 148: 3426 – 3440, 2007 (IF=5.045).
　　
　　13. Wang Y, Wang Z, Li J, Wang Y*, et al., A database for chicken full-length cDNAs. Physiological Genomics 28:141-5, 2007 (IF=3.368).
　　
　　14. Kwok AHY, Wang Y*, Wang CY, et al., Cloning of chicken glucocorticoid receptor (GR) and characterization of its expression in pituitary and extra-pituitary tissues. Poultry Science 86: 423-430, 2007 (IF=1.603).
15. Wang CY*, Wang Y*, Kwok AHY et al., Identification of two novel chicken GHRH receptor splice variants: implications for the roles of aspartate 56 in the receptor activation and direct ligand receptor interaction. Journal of Endocrinology 195: 525-536, 2007 (IF=2.636) (同等貢獻(xiàn)).
　　
　　16. Wang CY, Wang Y*, Li J et al. Expression profiles of chicken growth hormone-releasing hormone (GHRH) and growth hormone-releasing hormone receptor (GHRHR) during chicken embryonic pituitary development. Poultry Science, 85: 569-576, 2006, (IF=1.603).
　　
　　17. Kwok HF, So WK, Wang Y* et al, Zebrafish gonadotropins and their receptors: I. Cloning and characterization of zebrafish follicle-stimulating hormone and luteinizing hormone receptors: Evidence for their distinct functions in follicle development. Biology of Reproduction, 72: 1370-1381, 2005 (IF=3.670).
18. Wang Y* & Ge W Cloning of Epidermal growth factor (EGF) and EGF receptor from the zebrafish ovary: evidence for EGF as a potential paracrine factor from the oocyte to regulate activin/follistatin system in the follicle cells. Biology of Reproduction, 71: 749-760, 2004 (IF=3.670).
　　
　　19. Wang Y* & Ge W. Developmental profiles of activin βA, βB, and follistatin expression in the zebrafish ovary: evidence for their differential roles during sexual maturation and ovulatory cycle. Biology of Reproduction, 71: 2056-2064, 2004 (IF=3.670).
20. Wang Y* & Ge W. Cloning of zebrafish ovarian P450c17 (CYP17,17α-hydroxylase/17,20-lyase) and characterization of its expression in gonadal and extra-gonadal tissues. General and Comparative Endocrinology, 135: 241-249, 2004 (IF=3.108)
　　
　　21. Wang Y* & Ge W Involvement of cyclic adenosine 3’,5’-monophosphate in the differential regulation of activin βA and βB expression by gonadotropin in the zebrafish ovarian follicle cells. Endocrinology, 144: 491-499, 2003 (IF=5.045).
　　
　　22. Wang Y*, Wong AOL & Ge W Cloning, regulation of mRNA expression and function of a new isoform of pituitary adenylate cyclase-activating polypeptide (PACAP) in the zebrafish ovary. Endocrinology, 144: 4799-4810, 2003 (IF=5.045).
　　
　　23. Wang Y* & Ge W Spatial expression patterns of activin and its signaling system in the zebrafish ovarian follicle: Evidence for paracrine action of activin on the oocytes. Biology of Reproduction, 69: 1998-2006, 2003. (IF=3.670)
　　
　　24. Wang Y* & Ge W (2003) Gonadotropin regulation of follistatin expression in the cultured ovarian follicle cells of zebrafish, Danio rerio. General and Comparative Endocrinology, 134: 308-315 (IF=3.108)
　　
　　25. Wang Y* & Ge W. Cloning of zebrafish ovarian carbonyl reductase-like 20β-hydroxysteroid dehydrogenase and characterization of its spatial and temporal expression. General and Comparative Endocrinology, 127: 209-216, 2002 (IF=3.108).
　　
　　會(huì)議報(bào)告
　　1) 王亞軍 The 10th International Symposium on Avian Endocrinology 2012 (ISAE2012) (June 5-9, 2012, Japan).（大會(huì)報(bào)告, Invited speaker）Title: ‘Molecular characterization of the receptors for chicken GHRH, PrRP and their related peptides: An emerging evolutionary story’
獲獎(jiǎng):
　　2003年度 “香港中文大學(xué)研究生最佳研究成績(jī)獎(jiǎng)”
　　
　　
　　 

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