中山大學(xué)工學(xué)院導(dǎo)師：張心遠 正文

　　姓名：龔逸鴻　 性別：男　　職稱：副教授　　
　　學(xué)院：工學(xué)院　 最后學(xué)歷：博士
　　主要研究方向：再生醫(yī)學(xué)、生物材料、軟骨/骨組織工程、干細胞技術(shù)、細胞微載體技術(shù)。

基本情況


　　龔逸鴻，男，2006年畢業(yè)于浙江大學(xué)高分子系，獲材料物理與化學(xué)博士學(xué)位，畢業(yè)后赴新加坡南洋理工大學(xué)從事博士后研究，方向為可注射組織修復(fù)體系構(gòu)建及生物材料與細胞相互作用機制。2009年12月至中山大學(xué)工學(xué)院工作，為中山大學(xué)“百人計劃”引進人才，廣東納米力學(xué)和骨關(guān)節(jié)納米工程創(chuàng)新科研團隊核心成員，中山大學(xué)“985工程”三期建設(shè)項目生物醫(yī)學(xué)工程與力學(xué)創(chuàng)新平臺核心成員，中山大學(xué)“卓越人才計劃教師特別津貼”獲得者。

主持科研項目

1. 中山大學(xué)“985工程”三期提升自主創(chuàng)新和社會服務(wù)能力項目：生物醫(yī)學(xué)工程創(chuàng)新平臺 2010.1~2013.12，子項目負責(zé)人

2. 廣東省引進創(chuàng)新科研團隊項目：納米力學(xué)和骨關(guān)節(jié)納米工程創(chuàng)新科研團隊 2010.6～2014.6， 子項目負責(zé)人

3. 中山大學(xué)“百人計劃”項目，2010.1～2012.12 負責(zé)人

4. 國家自然科學(xué)基金-青年科學(xué)基金項目 可注射細胞微載體/水凝膠骨組織工程復(fù)合支架的研究，2012.1~2014.12，負責(zé)人

5. 國家自然科學(xué)基金-青年科學(xué)基金項目 納米纖維誘導(dǎo)肝臟細胞聚集體形成研究 2012.1~2014.12，主要參與人（排名2）

代表性論著

1. Su K., Gong Y.H.,* Wang C.M. Wang. D.A.. “A Novel Shell-structure Cell Microcarrier (SSCM) for Cell Transplantation and Bone Regeneration Medicine.” Pharm. Res. in press. DOI 10.1007/s11095-010-0321-5. (* 通訊作者 )

2. Gong Y.H.,** Su K., Lau T.T., Zhou R.J., Wang D.A.. “,Microcavitary Hydrogel-Mediating Phase Transfer Cell Culture for Cartilage Tissue Engineering.” Tissue Engineering Part A, 16 (2010), 12: 3611-3622 (**共同作者)

3. Gong Y.H., Wang C.M., Lai R.C., Su K., Zhang F. and Wang D.A. “An improved injectable polysaccharide hydrogel: modified gellan gum for long-term cartilage regeneration in vitro” J. Mater. Chem.” 2009, 2009, 19: 1968-1977.

~ Featured: Cover Story of Journal of Materials Chemistry, Vol. 19, Issue 14, 2009; and

~ Featured: Hot Paper in Category of “Biomaterials” of Journal of Materials Chemistry

(http://www.rsc.org/Publishing/Journals/jm/JMCHot_biomaterials.asp ); and

~Quoted: in “Application Highlights”, Chemical Technology, 6(2009), 3: T20.

(http://www.rsc.org/Publishing/ChemTech/Volume/2009/03/food_additive_promotes_tissue_regeneration.asp)

4. Gong Y.H., Ma. Z.W., Zhou Q.L., Li J., Gao C.Y., and Shen J.C. “Poly(lactic acid) scaffold fabricated by gelatin particle leaching has good biocompatibility for chondrogenesis ” J. Biomat. Sci. Polym. E 2008, 19: 207-221.

5. Gong Y.H., Zhu Y.B., Liu Y.X., Ma. Z.W., Gao C.Y., and Shen J.C. “Layer-by-layer assembly of chondroitin sulfate and collagen on aminolyzed poly(L-lactic acid) porous scaffolds to enhance their chondrogenesis” Acta Biomater. 2007, 3: 677-685.

6. Gong Y.H., He L.J., Li J., Ma Z.W., Gao C.Y., and Shen J.C. “Hydrogel-filled polylactide porous scaffolds for cartilage tissue engineering” J. Biomed. Mater. Res. B 2007, 82B: 192-204.

7. Gong Y.H., Zhou Q.L., Gao C.Y., and Shen J.C. “In vitro and in vivo degradability and cytocompatibility of poly(L-lactic acid) scaffold fabricated by a gelatin particle leaching method” Acta Biomater. 2007, 3: 531-540.

8. Gong Y.H., Ma. Z.W., Gao C.Y., Wang W. and Shen J.C. “Specially elaborated thermally induced phase separation to fabricate poly(L-lactic acid) scaffolds with ultra large pores and good interconnectivity” J. Appl. Polym. Sci. 2006, 101: 3336-3342.

9. Fan J.B., Gong Y.H., Ren L., Varshney R., Cai D.Z. and Wang D.A. “In Vitro Engineered Cartilage Using Synovium-Derived Mesenchymal Stem Cells with Injectable Gellan Hydrogels” Acta Biomater.2010: 6: 1178-1185.

10. Wang, C. M., Gong, YH., Zhong, Y., Yao, Y.C., Su, K. and Wang, DA.. “The control of anchorage-dependent cell behavior within a hydrogel / microcarrier system in an osteogenic model”, Biomaterials, 2009, 30: 2259-2269.

11. Hong Y., Gong Y.H., Gao C.Y. and Shen J.C. “Collagen-coated polylactide microcarriers/chitosan hydrogel composite: Injectable scaffold for cartilage regeneration” J. Biomed. Mater. Res. A. 2008, 85A: 628-637.

12. Wang C.M., Gong Y.H., Lin Y.M., Shen J.B. and Wang D.A. “A novel gellan gel-based microcarrier for anchorage-dependent cell delivery” Acta Biomater. 2008, 4: 1226-1234.

13. Tan H.P., Gong Y.H., Lao L.H., Ma Z.W., and Gao C.Y. “Gelatin/chitosan/hyaluronan ternary complex scaffold containing basic fibroblast growth factor for cartilage tissue engineering” J. Mater. Sci. Mater. M. 2007, 18: 1961-1968.

14. Zhou Q.L, Gong Y.H. and Gao C.Y.. “Microstructure and mechanical properties of poly(L-lactide) scaffolds fabricated by gelatin particle leaching method” J. Appl. Polym. Sci. 2005, 98: 1373-1379.

15. Hong Y., Gong Y.H., Gao C.Y., Jiacong Shen. Chitosan-modified polylactide microspheres: potentially injectable cell carriers for tissue engineering. Chinese Journal of Material Research 2005, 19: 589-593

16. Zhao, H.G., Ma, L., Gong, Y.H., Gao, C.Y., Shen, J.C. "A polylactide/fibrin gel composite scaffold for cartilage tissue engineering: fabrication and an in vitro evaluation" J. Biomat. Sci. Polym. E, 2009,20: 135-143

17. Wang C.M., Bai J., Gong Y.H., Zhang F., Shen J.B. and Wang D.A. “Enhancing Cell Affinity of Nonadhesive Hydrogel Substrate: The Role of Silica Hybridization” Biotechnol. Progr. 2008, 24:1142-1146.

~Featured: Cover Image of Biotechnology Progress, Vol. 25.

18. Hong Y., Song H.Q., Gong Y.H., Mao Z.W., Gao C.Y., and Shen J.C. “Covalently crosslinked chitosan hydrogel: Properties of in vitro degradation and chondrocyte encapsulation” Acta Biomater. 2007, 3: 23-31.

19. Ma. Z.W., Gao C.Y., Gong. Y.H., Shen J.C. “Cartilage tissue engineering PLLA scaffold with surface immobilized collagen and basic fibroblast growth factor “ Biomaterials 2005, 26:1253-1259.

20. Ma. Z.W., Gao C.Y., Gong. Y.H., Shen J.C. “Grafting and coating of collagen type I on poly-L-lactic acid (PLLA) membrane surface to enhance the growth of chondrocytes” Chemical journal of Chinese universities 2004, 25:749-752.

21. Ma. Z.W., Gao C.Y., Gong. Y.H., Shen J.C. “Chondrocyte behaviors on poly-L-lactic acid (PLLA) membranes containing hydroxyl, amide or carboxyl groups” Biomaterials 2003, 24: 3725-3730.

22. Ma. Z.W., Gao C.Y., Gong. Y.H., Shen J.C. “Paraffin spheres as porogen to fabricate poly(L-lactic acid) scaffolds with improved cytocompatibility for cartilage tissue engineering” J Biomed Mater Res B 2003,67B:610-617.

23. Ma. Z.W., Gao C.Y., Gong. Y.H., Shen J.C. “Immobilization of natural macromolecules on poly-L-lactic acid membrane surface in order to improve its cytocompatibility” J Biomed Mater Res 2002,63,838-847.

24. Shi, X.T., Wang, Y.J.,Varshney, R.R., Ren, L., Gong, Y.H. and Wang, D.A., “Microsphere-based Drug Releasing Scaffolds for Inducing Osteogenesis of Human Mesenchymal Stem Cells in vitro”, European Journal of Pharmaceutical Sciences, 2010, 29:59-67.

25. Shi, X.T., Wang, Y.J., Ren, L., Gong, Y H. and Wang, D.A., “A novel hydrophilic poly(lactide-co-glycolide)/lecithin hybrid microspheres sintered scaffold for bone repair”, Journal of Biomedical Materials Research Part A, 2010, 92A: 963-972.

26. Shi, X. T., Wang, Y. J., Ren, L., Zhao, N. R., Gong, Y.H. and Wang, D.A.*, “Novel Mesoporous Silica Based Antibiotic Releasing Scaffold for Bone Repair”, Acta Biomater. 2009, 5: 1697-1707.

27. Fan J.B., Ren L., Liang R.S., Gong Y.H., Cai D.Z. and Wang D.A.. Chondrogenesis of Synovium-Derived Mesenchymal Stem Cells in Photopolymerizing Hydrogel Scaffolds. J. Biomat. Sci. Polym. E 2010, 21: 1653-1667.

28. Zhang, F., Yao, Y. C., Hao, J. H., Zhou, R. J., Liu, C. Z., Gong, Y.H. and Wang, D.A., “A dual-functioning adenoviral vector encoding both transforming growth factor-β3 and shRNA silencing type I collagen: construction and controlled release for chondrogenesis” Journal of Controlled Release 2010, 142: 70-77.

29. Wang, C. M., Adrianus, G. N., Sheng, N., Toh, S. K., Gong, Y. H. and Wang, D. A.* “In vitro performance of an injectable hydrogel / microsphere based immunocyte delivery system for localised anti-tumour activity” Biomaterials 2009, 30: 6986-6995.

30. Shi X.T., Wang Y.J. Li R., Gong Y.H.and Wang D.A. “Novel Mesoporous Silica Based Antibiotic Releasing Scaffold for Bone Repair” Acta Biomater. 2009, 5:1697-1707.

31. Shi X.T., Wang Y.J. Li R., Gong Y.H. and Wang D.A. “Enhancing Alendronate Release from a Novel PLGA/Hydroxyapatite Microspheric System for Bone Repairing Applications” Pharm. Res. 2009, 26:422-430.

32. Tan H.P., Lao L.H., Wu J.D., Gong Y.H., and Gao C.Y. “Biomimetic modification of chitosan with covalently grafted lactose and blended heparin for improvement of in vitro cellular interaction” Polym. Advan. Technol. 2008, 19: 15-23.

33. Wang B., Hong Y., Feng J., Gong Y.H. and Gao C.Y. “Rings of hydrogel fabricated by a micro-transfer technique” Macromol. Rapid Comm. 2007, 28: 567-571.

34. Li J., Li J., Yu H.W., Cao H.C., Gao C.Y. and Gong Y. H. “Growth and metabolism of human hepatocytes on biomodified collagen poly(lactic-co-glycolic acid) three-dimensional scaffold” Asaio J. 2006, 52: 321-327.

35. Hong Y., Gao C.Y., Xie Y., Gong Y.H., and Shen J.C. “Collagen-coated polylactide microspheres as chondrocyte microcarriers” Biomaterials 2005, 26: 6305-6313.

36. Zhu Y.B., Gao C.Y., Liu Y.X., Gong. Y.H., Shen J.C. “LBL self-assembly of chondroitin sulfate and collagen onto poly(L-lactic acid) surface for improving its cytocompatibility with endothelial cells” Chemical journal of Chinese universities 2004, 25:1347-1350.

37. Li j., Sheng J.F., Gao C.Y., Gong Y.H., Yu H.Y, Li L.J. “Adhesion and function of human hepatocytes on biomodified collagen-poly (lactic acid) porous sponge scaffold” Xenotransplantation 2005,12: 402-402.

38. Ma Z.W., Gao C.Y., Juan J., Ji J., Gong Y.H. and Shen J.C. “Surface modification of poly-L-lactide by photografting of hydrophilic polymers towards improving its hydrophilicity” J. Appl. Polym. Sci. 2002, 85: 2163-2171.

獲得專利

1. 高長有，馬祖?zhèn)?，管建均，龔逸鴻，計劍，沈家? 光氧化接枝與生物活性因子固定化制備細胞相容性生物材料的方法，專利號：ZL 02136032.4，授權(quán)日：2004.9.1

2. 高長有，龔逸鴻，馬祖?zhèn)?，沈家? 組織工程用聚乳酸多孔支架的制備方法，專利號：ZL 02112497.3，授權(quán)日：2004.11.24

3. 高長有，馬祖?zhèn)ィ徱蔌?，沈家? 在聚合物生物材料表面穩(wěn)定涂層生物大分子的方法，專利號：ZL 03116450.1，授權(quán)日：2005.6.15

4. 高長有，馬祖?zhèn)?，龔逸鴻，沈家? 在聚合物生物材料表面引入細胞生長因子的方法，專利號：ZL 03117084.6，授權(quán)日：2005.8.31

5. 高長有，馬祖?zhèn)?，龔逸鴻，沈家? 蠟球致孔劑與熱致相分離結(jié)合制備聚合物多孔支架的方法，專利號：ZL 03116446.3，授權(quán)日：2005.11.9

6. 高長有，龔逸鴻，何麗娟，馬祖?zhèn)?，沈家? 將水凝膠復(fù)合到多孔組織工程支架中的方法，專利號：ZL 200410052984.4，授權(quán)日：2007.5.9

獲得獎勵

1. 2011 “聚合物組織工程和再生醫(yī)學(xué)材料的制備與性能”浙江省科學(xué)技術(shù)獎二等獎

2. 歐洲制藥學(xué)雜志2010年度最佳論文獎 (Best Paper Award from papers published in European Journal of Pharmaceutical Sciences during 2010)

3. 2011年入選中山大學(xué) “卓越人才計劃”

聯(lián)系方式

郵箱：gongyih@mail.sysu.edu.cn

中山大學(xué)

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