中國農(nóng)業(yè)大學農(nóng)學與生物技術學院博導：Patrick Schnable 正文

　　基本信息
　　姓名： Patrick Schnable
　　性別：男
　　系別：植物遺傳育種學系
　　職稱：長江學者
　　學位：博士
　　
　　個人簡歷
　　個人簡介
　　 2009年十一月合作完成了玉米自交系B73的測序工作，并于《Science》發(fā)表相關研究結果。
　　 2008年－今 中國農(nóng)業(yè)大學植物遺傳育種系長江學者講座教授，博士生導師；
　　 1988年－今 愛荷華州立大學（Iowa State University ）教授，植物基因組學研究中心主任，固碳作物研究中心主任；
　　 1986年－1988年在德國馬普研究所（Max-Planck-Institute）博士后;
　　 1986年 于愛荷華州立大學（Iowa State University ）獲得博士學位；
　　 1981年 于康奈爾大學（Cornell University ）獲得學士學位；
　　更多個人介紹內(nèi)容請訪問：http://schnablelab.plantgenomics.iastate.edu/personnel/schnable_patrick.php
　　
　　聯(lián)系方式
　　聯(lián)系方式：
　　實驗室網(wǎng)址：http://schnablelab.plantgenomics.iastate.edu/
　　電子信箱：schnable@iastate.edu
　　中國農(nóng)業(yè)大學實驗室地址：西校區(qū)農(nóng)學樓412房間
　　
　　研究方向
　?。?、玉米遺傳學和基因組學
　?。?、玉米功能基因組學
　?。?、比較基因組學
　　４、生物信息學

　　美國Iowa State University的Patrick Schnable教授是中國農(nóng)業(yè)大學農(nóng)學與生物技術學院植物遺傳育種系長江學者客座教授，是玉米基因組學、功能基因組學和雜種優(yōu)勢遺傳機理研究領域世界知名科學家。Patrick Schnable教授2011年在植物遺傳育種系繼續(xù)招收碩士研究生，在中國農(nóng)業(yè)大學完成碩士階段的學習和碩士研究論文工作，主要從事玉米基因組生物信息學相關研究，如通過全基因組序列分析，解析位點多態(tài)性與遺傳重組的關系等。Patrick Schnable教授主要通過來北京工作和網(wǎng)絡視頻實驗室會議等方式具體指導研究工作。具體要求：
　　 1、符合中國農(nóng)業(yè)大學2011年碩士研究生復試條件的第一志愿和調(diào)劑考生。
　　 2、有較強的英語交流能力。
　　 3、有良好的生物學基礎，對生物信息學和基因組學分析有濃厚興趣。
　　 4、有較強的計算機使用能力，熟悉或能較快掌握生物信息學軟件及其工作平臺（如Linux等），具備編程或能較快學習計算機編程能力。
　　 5、英文簡歷（Resume）和申請信（Personal statement )。

　　有意申請的考生請將簡歷和申請信發(fā)給Schnable教授（email: schnable@iastate.edu)，或直接到農(nóng)學樓412房間與Schnable教授在農(nóng)大已招在讀碩士研究生李德林（delin.bio@gmail.com）或黃銀連（yinlianhuang@gmail.com）聯(lián)系。通過初選的考生將由Schnable教授本人近日直接復試。Schnable教授在Iowa State University的具體情況見http://www.schnablelab.plantgenomics.iastate.edu/
　　 2011年3月1日
　　
　　論文著作
　　學術論文：
　　 2005 ~ 2010發(fā)表的論文：
　　詳細信息及下載請訪問：http://schnablelab.plantgenomics.iastate.edu/publications/
　　 2010 (7 篇)
　　 • Fu Y*, NM Springer*, K Ying*, CT Yeh, AL Iniguez, T Richmond, W Wu, WB Barbazuk, DS Nettleton, JA Jeddeloh, PS Schnable (2010) High-resolution genotyping via whole genome hybridizations to microarrays containing long oligonucleotide probes. PLoS One, 5(12): e14178.
　　 • Feuillet C, JE Leach, J Rogers, PS Schnable, K Eversole (2010) Crop genome sequencing: lessons and rationales. Trends Plant Sci, 16(2): 77-88.
　　 • Lai J*, R Li*, X Xu*, W Jin*, M Xu*, H Zhao, Z Xiang, W Song, K Ying, M Zhang, Y Jiao, P Ni, J Zhang, D Li, X Guo, K Ye, M Jian, B Wang, H Zheng, H Liang, X Zhang, S Wang, S Chen, J Li, Y Fu, NM Springer, H Yang, J Wang, J Dai, PS Schnable, J Wang (2010) Genome-wide patterns of genetic variation among elite maize inbred lines. Nat Genet, 42(11): 1027-1030. (Epub 2010 Oct 24 ; An image from this manuscript was selected for inclusion on the cover)
　　 • The International Brachypodium Initiative (2010) Genome sequencing and analysis of the model grass Brachypodium distachyon. Nature, 463(7282): 763-768.
　　 • Fu Y, NM Springer, D Gerhardt, K Ying, CT Yeh, W Wu, RA Swanson-Wagner, M D'Ascenzo, T Millard, L Freeberg, N Aoyama, J Kitzman, D Burgess, T Richmond, T Albert, WB Barbazuk, JA Jeddeloh, PS Schnable (2010) Repeat subtraction-mediated sequence capture from a complex genome. Plant J, 62(5): 898-909. (Epub: 4 Mar 2010; An image from this manuscript was selected for inclusion on the cover)
　　 • Liu S, HD Chen, I Makarevitch, R Shirmer, SJ Emrich, CR Dietrich, WB Barbazuk, NM Springer, PS Schnable (2010) High-throughput genetic mapping of mutants via quantitative single nucleotide polymorphism typing. Genetics, 184: 19-26.
　　 • Buggs RJA, S Chamala, W Wu, L Gao, GD May, PS Schnable, DE Soltis, PS Soltis, WB Barbazuk (2010) Characterization of duplicate gene evolution in the recent natural allopolyploid Tragopogon miscellus by next-generation sequencing and Sequenom iPLEX MassARRAY genotyping. Molecular Ecology, 19(s1): 132-146.
　　 2009 (16 篇)
　　 • Liu S, CR Dietrich, PS Schnable (2009) DLA-based strategies for cloning insertion mutants: cloning the gl4 locus of maize using Mu transposon tagged alleles. Genetics, 183: 1215-1225. (Selected as an Editors' Choice by MaizeGDB, 11/09)
　　 • Schnable PS*, D Ware*, RS Fulton, et al (2009) The B73 maize genome: complexity, diversity and dynamics. Science, 326(5956): 1112-1115. (Highlighted by Faculty of 1000 Biology; An image from this manuscript was selected for inclusion on the cover)
　　 • Jia Y, DR Lisch, K Ohtsu, MJ Scanlon, DS Nettleton, PS Schnable (2009) Loss of RNA-dependent RNA Polymerase 2 (RDR2) function causes widespread and unexpected changes in the expression of transposons, genes and 24-nt small RNAs. PLoS Genetics, 5(11): e1000737. (Selected as an Editors' Choice by MaizeGDB, 12/09)
　　 • Wei F, JC Stein, .. PS Schnable,.. et al (2009) Detailed analysis of a contiguous 22-Mb region of the maize genome. PLoS Genetics, 5(11): e1000728. (Selected as an Editors' Choice by MaizeGDB, 12/09)
　　 • Swanson-Wagner RA, R DeCook, Y Jia, T Bancroft, T Ji, X Zhao, DS Nettleton, PS Schnable (2009) Paternal dominance of trans-eQTL influences gene expression patterns in maize hybrids. Science, 326(5956): 1118-1120. (Highlighted by Faculty of 1000 Biology)
　　 • Springer NM*, K Ying*, Y Fu, T Ji, CT Yeh, Y Jia, W Wu, T Richmond, J Kitzman, H Rosenbaum, AL Iniguez, WB Barbazuk, JA Jeddeloh, DS Nettleton, PS Schnable (2009) Maize inbreds exhibit high levels of CNV and presence/absence differences in genome content. PLoS Genetics, 5(11): e1000734. (Selected as an Editors' Choice by MaizeGDB, 12/09)
　　 • Wei F, J Zhang, S Zhou, R He, ML Schaeffer, K Collura, D Kudrna, BP Faga, M Wissotski, W Golser, SM Rock, TA Graves, RS Fulton, E Coe, PS Schnable, DC Schwartz, D Ware, SW Clifton, RK Wilson, RA Wing (2009) The physical and genetic framework of the maize B73 genome. PLoS Genetics, 5(11): e1000715. (Selected as an Editors' Choice by MaizeGDB, 12/09)
　　 • Liu S, CT Yeh, T Ji, K Ying, H Wu, HM Tang, Y Fu, DS Nettleton, PS Schnable (2009) Mu transposon insertion sites and meiotic recombination events co-localize with epigenetic markers for open chromatin across the maize genome. PLoS Genetics, 5(11): e1000733. (Selected as an Editors' Choice by MaizeGDB, 12/09)
　　 • Chou HH, A Trisiriroj, S Park, YIC Hsing, PC Ronald, PS Schnable (2009) Direct calibration of PICKY-designed microarrays. BMC Bioinformatics, 10(34).
　　 • Soltis DE, RJA Buggs, WB Barbazuk, PS Schnable, PS Soltis (2009) On the origins of species: does evolution repeat itself in polyploid populations of independent origin?. Cold Spring Harbor Symposia on Quantitative Biology.
　　 • Scanlon MJ, K Ohtsu, MCP Timmermans, PS Schnable (2009) Laser microdissection-mediated isolation and in vitro transcriptional amplification of plant RNA. Curr Protoc Mol Biol, Unit 25A.3.
　　 • Brooks III L, J Strable, X Zhang, K Ohtsu, R Zhou, A Sarkar, S Hargreaves, RJ Elshire, D Eudy, T Pawlowska, D Ware, D Janick-Buckner, B Buckner, MCP Timmermans, PS Schnable, DS Nettleton, MJ Scanlon (2009) Microdissection of shoot meristem functional domains. PLoS Genetics, 5(5): e1000476. (Epub: 8 May 2009)
　　 • Wei Y, M Lin, DJ Oliver, PS Schnable (2009) The Roles of aldehyde dehydrogenases (ALDHs) in the PDH bypass of arabidopsis. BMC Biochemistry, 10(7).
　　 • Nogueira FTS, DH Chitwood, S Madi, K Ohtsu, PS Schnable, MJ Scanlon, MCP Timmermans (2009) Regulation of small RNA accumulation in the maize shoot apex. PLoS Genetics, 5(1): e1000320. (Selected as an Editors' Choice by MaizeGDB, 6/09)
　　 • Shimizu R, J Ji, E Kelsey, K Ohtsu, PS Schnable, MJ Scanlon (2009) Tissue specificity and evolution of meristematic WOX3 function. Plant Physiol, 149(2): 841-850. (Highlighted by Faculty of 1000 Biology)
　　 • Jackson BG, PS Schnable, S Aluru (2009) Parallel short sequence assembly of transcriptomes. BMC Bioinformatics, 10(Suppl 1): S14.
　　 2008 (8 篇)
　　 • Skibbe DS, X Wang, LA Borsuk, DA Ashlock, DS Nettleton, PS Schnable (2008) Floret-specific differences in gene expression and support for the hypothesis that tapetal degeneration of Zea mays L. occurs via programmed cell death. Journal of Genetics and Genomics, 35(10): 603-616.
　　 • Jung KH, CD Dardick, LE Bartley, P Cao, J Phetsom, P Canlas, YS Seo, M Shultz, S Ouyang, Q Yuan, BC Frank, E Ly, L Zheng, Y Jia, AP Hsia, K An, HH Chou, D Rocke, GC Lee, PS Schnable, G An, CR Buell, PC Ronald (2008) Refinement of light-responsive transcript lists using rice oligonucleotide arrays: evaluation of gene-redundancy. PLoS One, 3(10): e3337.
　　 • Strable J, LA Borsuk, DS Nettleton, PS Schnable, EE Irish (2008) Microarray analysis of vegetative phase change in maize. Plant J, 56(6): 1045-1057.
　　 • Lu R, GC Lee, M Shultz, CD Dardick, KH Jung, J Phetsom, Y Jia, RH Rice, Z Goldberg, PS Schnable, PC Ronald, D Rocke (2008) Assessing probe-specific dye and slide biases in two-color microarray data. BMC Bioinformatics, 9(314).
　　 • Buckner B, KA Swaggart, CC Wong, HA Smith, KM Aurand, MJ Scanlon, PS Schnable, D Janick-Buckner (2008) Expression and nucleotide diversity of the maize RIK gene. J Hered, 99(4): 407-416. (Epub: 2008 Feb 28)
　　 • Hochholdinger F, TJ Wen, R Zimmermann, P Chimit-Marolle, O da Costa e Silva, W Bruce, KR Lamkey, U Wienand, PS Schnable (2008) The maize (Zea mays L.) roothairless3 gene encodes a putative GPI-anchored, monocot-specific, COBRA-like protein that significantly affects grain yield. Plant J, 54(5): 888-898. (Selected as an Editors' Choice by MaizeGDB, 6/08)
　　 • Li J, TJ Wen, PS Schnable (2008) The role of RAD51 in the repair of MuDR-induced double-strand breaks in maize (Zea mays L.). Genetics, 178(1): 57-66. (Selected as an Editors' Choice by MaizeGDB, 2/08)
　　 • Jackson BG, S Aluru, PS Schnable (2008) Consensus genetic maps as median orders from inconsistent sources. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 5(2): 161-171.
　　 2007 (12 篇)
　　 • Dembinsky D, K Woll, M Saleem, Y Liu, Y Fu, LA Borsuk, T Lamkemeyer, C Fladerer, J Madlung, WB Barbazuk, A Nordheim, DS Nettleton, PS Schnable, F Hochholdinger (2007) Transcriptomic and proteomic analyses of pericycle cells of the maize primary root. Plant Physiol, 145(3): 575-588.
　　 • Ohtsu K, MB Smith, SJ Emrich, LA Borsuk, R Zhou, T Chen, X Zhang, MCP Timmermans, J Beck, B Buckner, D Janick-Buckner, DS Nettleton, MJ Scanlon, PS Schnable (2007) Global gene expression analysis of the shoot apical meristem of maize (Zea Mays L.). Plant J, 52(3): 391-404. (Highlighted by Faculty of 1000 Biology)
　　 • Barbazuk WB, SJ Emrich, HD Chen, L Li, PS Schnable (2007) SNP discovery via 454 transcriptome sequencing. Plant J, 51(5): 910-918. (Cited in Wikipedia: http://en.wikipedia.org/wiki/RNA-Seq)
　　 • Zhang X, S Madi, LA Borsuk, DS Nettleton, B Buckner, D Janick-Buckner, J Beck, MCP Timmermans, PS Schnable, MJ Scanlon (2007) Laser microdissection of narrow sheath mutant maize uncovers novel gene expression in the shoot apical meristem. PLoS Genetics, 3(6): 1040-1052. (Selected an Editors' Choice by MaizeGDB, 7/07)
　　 • Li J, LC Harper, I Golubovskaya, CR Wang, D Weber, RB Meeley, J McElver, B Bowen, WZ Cande, PS Schnable (2007) Functional analysis of maize RAD51 in meiosis and double-strand break repair. Genetics, 176(3): 1469-1482. (Selected by editors of Genetics as an "Issue Highlight"; selected as an Editors'Choice by MaizeGDB, 8/07)
　　 • Buckner B, J Beck, KF Browning, AE Fritz, L Grantham, E Hoxha, Z Kamvar, A Lough, O Nikolova, PS Schnable, MJ Scanlon, D Janick-Buckner (2007) Involving undergraduates in the annotation and analysis of global gene expression studies: creation of a maize shoot apical meristem expression database. Genetics, 176(2): 741-747.
　　 • Li J, AP Hsia, PS Schnable (2007) Recent advances in plant recombination. Current Opinion in Plant Biology, 10(2): 131-135. (Epub: 2007 Feb 8)
　　 • Travers SE, MD Smith, J Bai, SH Hulbert, JE Leach, PS Schnable, AK Knapp, GA Milliken, PA Fay, A Saleh, KA Garrett (2007) Ecological genomics: making the leap from model systems in the lab to native populations in the field. Front Ecol Environ, 5(1): 19-24.
　　 • Ohtsu K, H Takahashi, PS Schnable, M Nakazono (2007) Cell type-specific gene expression profiling in plants by using a combination of laser microdissection and high-throughput technologies. Plant Cell Physiol, 48(1): 3-7. (Epub: 2006 Dec 5)
　　 • Emrich SJ*, L Li*, TJ Wen, MD Yandeau-Nelson, Y Fu, L Guo, HH Chou, S Aluru, DA Ashlock, PS Schnable (2007) Nearly identical paralogs (NIPs) and implications for maize genome evolution. Genetics, 175(1): 429-439. (Featured in Science(315:302) as in Editor's Choice: Highlights of the recent literature; selected as an Editors' Choice by MaizeGDB, 12/06)
　　 • Emrich SJ*, WB Barbazuk*, L Li, PS Schnable (2007) Gene discovery and annotation using LCM-454 transcriptome sequencing. Genome Res, 17(1): 69-73. (Epub: 2006 Nov 9)
　　 • Kalyanaraman A, SJ Emrich, PS Schnable, S Aluru (2007) Assembling genomes on large-scale parallel computers. Journal of Parallel and Distributed Computing, 67: 1240-1255. (Special issue devoted to IPDPS best papers)
　　 2006 (7 篇)
　　 • Fu Y, TJ Wen, YI Ronin, HD Chen, L Guo, DI Mester, Y Yang, M Lee, AB Korol, DA Ashlock, PS Schnable (2006) Genetic dissection of intermated recombinant inbred lines using a new genetic map of maize. Genetics, 174(3): 1671-1683. (Epub: 2006 Sep 1)
　　 • Kalyanaraman A, S Aluru, PS Schnable (2006) Turning repeats to advantage: scaffolding genomic contigs using LTR retrotransposons. Comput Syst Bioinformatics Conf, 5: 167-178. (Conference Website)
　　 • Yandeau-Nelson MD, BJ Nikolau, PS Schnable (2006) Effects of trans-acting genetic modifiers on the rates and distribution of meiotic recombination across the a1-sh2 interval of maize. Genetics, 174(1): 101-112. (Epub: 2006 Jul 2. Highlighted by Faculty of 1000 Biology)
　　 • Yandeau-Nelson MD, Y Xia, J Li, MG Neuffer, PS Schnable (2006) Unequal sister chromatid and homolog recombination at a tandem duplication of the a1 locus in maize. Genetics, 173(4): 2211-2226. (Epub: 2006 Jun 4)
　　 • Skibbe DS, X Wang, X Zhao, LA Borsuk, DS Nettleton, PS Schnable (2006) Scanning microarrays at multiple intensities enhances discovery of differentially expressed genes. Bioinformatics, 22(15): 1863-1870. (Epub: 2006 May 26)
　　 • Swanson-Wagner RA*, Y Jia*, R DeCook, LA Borsuk, DS Nettleton, PS Schnable (2006) All possible modes of gene action are observed in a global comparison of gene expression in a maize F1 hybrid and its inbred parents. PNAS, 103(18): 6805-6810. (Epub: 2006 Apr 25. Highlighted by Faculty of 1000 Biology)
　　 • Maher PM, HH Chou, E Hahn, TJ Wen, PS Schnable (2006) GRAMA: A genetic mapping tool for the analysis of temperature gradient capillary electrophoresis (TGCE) data. Theor Appl Genet, 113(1): 156-162. (Epub: 2006 Apr 20)
　　 2005 (13篇)
　　 • Ashlock DA, RA Swanson-Wagner, PS Schnable (2005) Selection of genetically diverse recombinant inbreds with an ordered gene evolutionary algorithm. CIBCB'05: 237-242.
　　 • Hochholdinger F, K Woll, L Guo, PS Schnable (2005) The accumulation of abundant soluble proteins changes early in the development of the primary roots of maize (Zea mays L.). Proteomics, 5(18): 4885-4893. (An image from this manuscript was selected for inclusion on the cover)
　　 • Woll K, LA Borsuk, H Stransky, DS Nettleton, PS Schnable, F Hochholdinger (2005) Isolation, characterization, and pericycle-specific transcriptome analyses of the novel maize (Zea Mays L.) lateral and seminal root initiation mutant rum1. Plant Physiol, 139(3): 1255-1267.
　　 • Fu Y*, SJ Emrich*, L Guo, TJ Wen, S Aluru, DA Ashlock, PS Schnable (2005) Quality assessment of maize assembled genomic islands (MAGIs) and large-scale experimental verification of predicted genes. PNAS, 102(34): 12282-12287.
　　 • Jackson BG, S Aluru, PS Schnable (2005) Consensus genetic maps: a graph theoretic approach. Comput Syst Bioinformatics Conf: 35-43.
　　 • Wen TJ, F Hochholdinger, M Sauer, W Bruce, PS Schnable (2005) The roothairless1 gene of maize (Zea mays) encodes a homolog of sec3, which is involved in polar exocytosis. Plant Physiol, 138(3): 1637-1643. (Epub: 2005 Jun 24; Selected as an Editors' Choice by MaizeGDB, 4/07)
　　 • Hsia AP, TJ Wen, HD Chen, Z Liu, MD Yandeau-Nelson, Y Wei, L Guo, PS Schnable (2005) Temperature Gradient Capillary Electrophoresis (TGCE) - A tool for the high throughput discovery and mapping of SNPs and IDPs. Theor Appl Genet, 111(2): 218-225.
　　 • Ding J, K Viswanathan, D Berleant, ES Wurtele, DA Ashlock, JA Dickerson, A Fulmer, PS Schnable (2005) Using the biological taxonomy to access biological literature with PathBinderH. Bioinformatics, 21(10): 2560-2562.
　　 • Dietrich CR, MA Perera, MD Yandeau-Nelson, RB Meeley, BJ Nikolau, PS Schnable (2005) Characterization of two gl8 paralogs reveals that the 3-ketoacyl reductase component of fatty acid elongase is essential for maize (Zea mays L.) development. Plant J, 42(6): 844-861.
　　 • Yao H, PS Schnable (2005) Cis-effects on meiotic recombination across distinct a1-sh2 intervals in a common Zea genetic background. Genetics, 170(4): 1929-1944.
　　 • Yao H, L Guo, Y Fu, LA Borsuk, TJ Wen, DS Skibbe, X Cui, BE Scheffler, J Cao, SJ Emrich, DA Ashlock, PS Schnable (2005) Evaluation of five ab initio gene prediction programs for the discovery of maize genes. Plant Mol Biol, 57(3): 445-460.
　　 • Yandeau-Nelson MD, Q Zhou, H Yao, X Xu, BJ Nikolau, PS Schnable (2005) MuDR transposase increases the frequency of meiotic crossovers in the vicinity of a Mu insertion in the maize a1 gene. Genetics, 169(2): 917-929.
　　 • Skibbe DS, PS Schnable (2005) Male sterility in maize. Maydica, 50: 367-376.
　　  

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