天津科技大學(xué)生物工程學(xué)院導(dǎo)師：謝希賢 正文

[導(dǎo)師姓名]
謝希賢

[所屬院校]
天津科技大學(xué)

[基本信息]
導(dǎo)師姓名：謝希賢
性別：男
人氣指數(shù)：488
所屬院校：天津科技大學(xué)
所屬院系：生物工程學(xué)院
職稱：教授
導(dǎo)師類型：
招生專業(yè)：微生物與生化藥學(xué)

[通訊方式]
辦公電話：022-60601251
電子郵件：xixianxie@tust.edu.cn
通訊地址：天津經(jīng)濟(jì)技術(shù)開發(fā)區(qū)第十三大街29號(hào)，天津科技大學(xué)生物工程學(xué)院

[個(gè)人簡(jiǎn)述]
發(fā)明申請(qǐng)專利：[1]谷氨酸棒桿菌及采用該菌發(fā)酵生產(chǎn)α-酮戊二酸的方法，ZL201110392778.8。[2]解淀粉芽孢桿菌添加前體物發(fā)酵法生產(chǎn)抗病毒藥物利巴韋林的生產(chǎn)工藝，ZL201310097836.3。[3]利用重組表達(dá)核糖磷酸酶生產(chǎn)5-肌苷酸的方法，ZL201410032597.8。[4]Hydroxy-and dicarboxylic-fat synthesis by microbes US 2015/0225753 A1.[5]一種L-異亮氨酸羥化酶基因及其基因工程菌與應(yīng)用，ZL201410132444.0。[6]一株產(chǎn)α-酮基丁酸的基因工程菌及其應(yīng)用，201410132996.1。[7]一種產(chǎn)生四氫嘧啶的基因工程菌及其構(gòu)建方法與應(yīng)用，201510410080.2。[8]一種耐酸性蘇氨酸生產(chǎn)菌及其構(gòu)建方法與應(yīng)用，201510579005.9。[9]一種α-酮基丁酸發(fā)酵生產(chǎn)工藝，201510579553.1。[10]一種羥基四氫嘧啶的制備方法，201510638769.0獲獎(jiǎng)情況：[1]芳香族氨基酸及衍生物關(guān)鍵技術(shù)研究與產(chǎn)業(yè)化，中國(guó)輕工業(yè)聯(lián)合會(huì)，科技進(jìn)步獎(jiǎng)，一等獎(jiǎng)，2015。[2]谷氨酸清潔生產(chǎn)和廢水綜合利用關(guān)鍵技術(shù)研究與應(yīng)用，中國(guó)輕工業(yè)聯(lián)合會(huì)，科技進(jìn)步獎(jiǎng)，二等獎(jiǎng)，2015。[3]分支鏈氨基酸代謝調(diào)控技術(shù)及產(chǎn)業(yè)化，天津市，科技進(jìn)步獎(jiǎng)，二等獎(jiǎng)，2013。[4]谷氨酸棒桿菌蘇氨酸脫氨酶基因敲除及對(duì)L-亮氨酸發(fā)酵的影響，中國(guó)食品科學(xué)技術(shù)學(xué)會(huì)，科技創(chuàng)新獎(jiǎng)，一等獎(jiǎng)，2011。[5]梅花味精教師獎(jiǎng)，二等獎(jiǎng)，2009。

[科研工作]
[1]Ning Y Wu X Zhang C Xu Q Chen N* Xie X*. Pathway construction and metabolic engineering for fermentativeproduction of ectoine inEscherichia coli. Metabolic Engineering 2016 36:10-18.IF: 6.767[2]ZhangC Qi J Li Y Fan X Xu Q Chen N Xie X*. Production of α-ketobutyrate using engineered Escherichia coli via temperature shift. Biotechnology and Bioengineering 2016 doi: 10.1002/bit.25959. IF: 4.126[3]Gui Y Ma Y Xu Q Zhang C Xie X* Chen N. Complete genome sequence of Corynebacterium glutamicum CP a Chinese l-leucine producing strain. Journal of Biotechnology 2016 220:64-65. IF: 2.871[4]Li Y Sun L Feng J Wu R Xu Q Zhang C Chen N Xie X*. Efficient production of α-ketoglutarate in the gdh deleted Corynebacterium glutamicum by novel double-phase pH and biotin control strategy. Bioprocess and Biosystems Engineering 2016 doi:10.1007/s00449-016-1576-y. IF: 1.997[5]Zhang C Du S Liu Y Xie X Xu Q Chen N*. Strategy for enhancing adenosine production under the guidance of transcriptional and metabolite pool analysis. Biotechnol Lett. 2015 37(7):1361-1369. IF: 1.591[6]Wang J Wen B Xu Q Xie X Chen N*. Optimization of carbon source and glucose feeding strategy for improvement of L-isoleucine production by Escherichia coli. Biotechnol Biotechnol Equip. 2015 29(2):374-380.[7]Xie X Liang Y Liu H Liu Y Xu Q Zhang C Chen N.*Modification of glycolysis and its effect on the production of L-threonine in Escherichia coli. J Ind Microbiol Biotechnol 2014 41:1007-1015. IF: 2.439[8]Ma Y Yang S Liu L Xu Q Zhang C Chen N Xie X*. Fermentative production of ribavirin by overexpressing purine nucleoside phosphorylase in Bacillus.J Chem Pharm Res 2014 6(5):1377-1384. EI[9]Xu L Xie X Shi J Xu Q Chen N*.Expression of the Escherichia coli tdcB gene encoding threoninedehydratase in L-isoleucineoverproducingCorynebacterium Glutamicum Yilw. Appl Biochem Microbiol 2013 49(2) 125-129. IF: 0.658[10]Wang J Wen B Wang Jian Xu Q Zhang C Chen N XieX*. Enhancing l-isoleucine production bythrABCoverexpression combined withalaTdeletion inCorynebacterium glutamicum. Appl Biochem Biotech 2013 171(1):20-30.IF: 1.893[11]Cheng Y Zhou Y Yang L Zhang C Xu Q Xie X Chen N*. Modification of histidine biosynthesis pathway genes and the impact on production of L-histidine in Corynebacterium glutamicum. Biotechnol Lett. 2013 5(5):735-741. IF: 1.736[12]Guo X Wang J Xie X Xu Q Zhang C Chen N*. Enhancing the supply of oxaloacetate for L-glutamate production by pyc overexpression in different Corynebacterium glutamicum.Biotechnol Lett. 2013 35(6):943-950. IF: 1.736[13]Fang H Liu H Chen N* Zhang C Xie X Xu Q. Site-directed mutagenesis studies on the uridine monophosphate binding sites of feedback inhibition in carbamoyl phosphate synthetase and effects on cytidine production by Bacillus amyloliquefaciens. Can J Microbiol. 2013 59(6):374-9. IF: 1.182[14]Liang J Zhang D Guo X Xu Q Xie X Zhang C Bai G Xiao X Chen N*. At-line near-infrared spectroscopy for monitoring concentrations in temperature-triggered glutamate fermentation. Bioprocess Biosyst Eng. 2013 36(12):1879-1887. IF: 1.823[15]Fang H Xie X Xu Q Zhang C Chen N*. Enhancement of cytidine production by coexpression of gnd zwf and prs genes in recombinant Escherichia coli CYT15. Biotechnol Lett. 2013 35(2):245-251. IF: 1.736[16]Liu Q Cheng Y Xie X Xu Q Chen N*. Modification of tryptophan transport system and its impact on production of L-tryptophan in Escherichia coli. Bioresour Technol.2012 114:549-554.IF: 4.75[17]Xie X Huo W Xia J Xu Q Chen N*. Structure-activity relationship of a cold-adapted purine nucleoside phosphorylase by site-directed mutagenesis. Enzyme Microb Technol.2012 51(1):59-65.IF: 2.592[18]Xie X Xu L Shi J Xu Q Chen N*. Effect of transport proteins on L-isoleucine production with the L-isoleucine-producing strain Corynebacterium glutamicumYILW. J Ind Microbiol Biotechnol. 2012 39(10): 1549-1556. IF: 2.321[19]Shen T Liu Q Xie X Xu Q Chen N*. Improved production of tryptophan in genetically engineered Escherichia coli with TktA and PpsA overexpression. J Biomed Biotechnol. 2012 2012:605219. IF: 2.88[20]Xie X Xia J Xu Q He K Lu L Chen N*. Low-molecular-mass homotrimer purine nucleotide phosphorylase: characterization and application in enzymatic synthesis of nucleoside antiviral drugs. Biotechnol Lett. 2011 33(6):1107-1112. IF: 1.683[21]Xie X Wang G Xia J Chen N. Characterization of a recombinant cold-adapted purine nucleoside phosphorylase and its application in ribavirin bioconversion. World J Microbiol Biotechnol. 2011 27:1175-1181. IF: 1.532[22]Chen N* Xing C Xie X Xu Q. Optimization of technical conditions of producing ribavirin by Bacillussubtilis. Ann Microbiol 2009 59(3):525-530.[23]Xie X Xu L Yang F*. 2006. Proteomic analysis of the major envelope and nucleocapsid proteins of white spot syndrome virus (WSSV). J. Virol. 80:10615-10623.[24]Xie X Yang F*. 2006. White spot syndrome virus VP24 interacts with VP28 and is involved in virus infection. J. Gen. Virol. 87:1903-1908.[25]Xie X Yang F*. 2005. Interaction of white spot syndrome virus VP26 protein with actin. Virology 336:93-99.[26]Xie X Li H Xu L Yang F*. 2005. A simple and efficient method for purification of intact white spot syndrome virus (WSSV) viral particles. Virus Res. 108:63-67.

[教育背景]
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