天津科技大學(xué)生物工程學(xué)院導(dǎo)師：劉夫鋒

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天津科技大學(xué)生物工程學(xué)院導(dǎo)師：劉夫鋒正文

[導(dǎo)師姓名]
劉夫鋒

[所屬院校]
天津科技大學(xué)

[基本信息]
導(dǎo)師姓名：劉夫鋒
性別：男
人氣指數(shù)：1102
所屬院校：天津科技大學(xué)
所屬院系：生物工程學(xué)院
職稱：教授
導(dǎo)師類型：
招生專業(yè)：藥理學(xué)
研究領(lǐng)域：[1]蛋白質(zhì)聚集及抑制[2]酶工程

[通訊方式]
電子郵件：fufengliu@tust.edu.cn

[個人簡述]
獲獎情況先后榮獲天津大學(xué)本科畢業(yè)設(shè)計優(yōu)秀指導(dǎo)教師Hong Kong Scholars Annual Symposium Best poster津大學(xué)北洋學(xué)者青年骨干教師（第一批）天津大學(xué)第九屆青年教師講課大賽，天津大學(xué)三等獎天津大學(xué)第九屆青年教師講課大賽，化工學(xué)院一等獎寶舜獎教金天津大學(xué)大學(xué)生創(chuàng)新性實踐計劃項目優(yōu)秀指導(dǎo)教師天津大學(xué)本科畢業(yè)設(shè)計優(yōu)秀指導(dǎo)教師。

[科研工作]
先后發(fā)表SCI檢索論文50余篇，參編教材或?qū)Ｖ?部，授權(quán)或申請發(fā)明專利7項。近年來發(fā)表的主要代表性學(xué)術(shù)論文有：[1] N. Xiong X.-Y. Dong J. Zheng F.-F. Liu* and Y. Sun*. Design of LVFFARK and LVFFARK- functionalized nanoparticles for inhibiting amyloid β-protein fibrillation and cytotoxicity ACS Applied Materials & Interfaces 2015 7(10): 5650-5662 SCI 1區(qū) Impact factor: 8.097[2] Junying Wang Ying Zhang Xingji Wang Jinzhao Shang Yu Li Huitu Zhang Fuping Lu* F.-F. Liu*. Biochemical characterization and molecular mechanism of acid denaturation of a novel α-amylase from Aspergillus niger Biochemical Engineering Journal 2018 137: 222-231. SCI 2區(qū) Impact factor: 3.226[3] H. Qin Z. Zhu Z. Ma P. Xu Q. Guo S. Li J. Wang S. Mao F.-F. Liu* F.-P. Lu*. Rational design of cholesterol oxidase for efficient bioresolution of cholestane skeleton substrates Scientific Reports 2017 7: 16375 SCI 3區(qū) Impact factor: 4.122[4] Y.-L. Tu S. Ma F.-F. Liu * Y. Sun X.-Y. Dong*. Hematoxylin Suppresses Amyloid β-Protein Aggregation and Reduces Amyloid Cytotoxicity The Journal of Physical Chemistry B 2016 120 (44) 11360–11368. SCI 2區(qū) Impact factor: 3.603[5] N. Zhang F.-F. Liu* X.-Y. Dong and Y. Sun*. Synergistic inhibition of acid-induced protein denaturation by trehalose and NaCl: thermodynamic and kinetic studies Biochemical Engineering Journal 2014 91: 231-239 SCI 2區(qū) Impact factor: 3.226[6] W.-J. Du J.-J. Guo M.-T. Gao S.-Q. Hu X.-Y. Dong Y.-F. Han F.-F. Liu* S. Jiang* Y. Sun*. Brazilin inhibits amyloid β-protein fibrillogenesis remodels amyloid fibrils and reduces amyloid cytotoxicity Scientific Reports 2015 5: 7992. SCI 2區(qū) Impact factor: 5.578[7] N. Xiong X.-Y. Dong J. Zheng F.-F. Liu* and Y. Sun*. Design of LVFFARK and LVFFARK-functionalized nanoparticles for inhibiting amyloid β-protein fibrillation and cytotoxicity ACS Appl. Mater. Inter. 2015 7(10): 5650-5662. SCI 1區(qū) Impact factor: 7.145[8] N. Zhang F.-F. Liu* X.-Y. Dong and Y. Sun*. Synergistic inhibition of acid-induced protein denaturation by trehalose and NaCl: thermodynamic and kinetic studies Biochemical Engineering Journal 2014 91: 231-239. SCI 2區(qū) Impact factor: 2.467[9] W.-W. Zhao F.-F. Liu* Q.-H. Shi X.-Y. Dong and Y. Sun*. Biomimetic design of affinity peptide ligands for human IgG based on Protein A-IgG complex. Biochemical Engineering Journal 2014 88: 1-11. SCI 2區(qū) Impact factor: 2.467[10] N. Zhang F.-F. Liu* X.-Y. Dong and Y. Sun*. Counteraction of Trehalose on Urea-Induced Protein Unfolding: Thermodynamic and Kinetic Studies Biochemical Engineering Journal 2013 79(15): 120-128. SCI 2區(qū) Impact factor: 2.467[11] J.-J. Guo# W.-Q. Sun# F.-F. Liu*. Brazilin inhibits the Zn2+-mediated aggregation of amyloid β-protein and alleviates cytotoxicity Journal of Inorganic Biochemistry 2017 177: 183-189 SCI 2區(qū) Impact factor:3.063[12] S.-Y. Chang F.-F. Liu* X.-Y. Dong and Y. Sun*. Molecular insight into conformational transmission of human P-glycoprotein The Journal of Chemical Physics 2013 139（22）：225102. (Cover page) SCI 2區(qū) Impact factor: 3.122[13] F.-F. Liu B. Huang X.-Y. Dong and Y. Sun*. Molecular Basis for the Dissociation Dynamics of Protein A-Immunoglobulin G1 Complex. Plos One 2013 8(6): e66935. SCI 2區(qū) Impact factor: 4.411[14] N. Zhang F.-F. Liu* X.-Y. Dong and Y. Sun*. Equilibrium and kinetic studies of the counteraction of trehalose on acid-induced protein unfolding. Biochemical Engineering Journal 2013 70: 188-195. SCI 2區(qū) Impact factor: 2.467[15] N. Zhang F.-F. Liu* X.-Y. Dong and Y. Sun*. Molecular Insight into the Counteraction of Trehalose on Urea-Induced Protein Denaturation Using Molecular Dynamics Simulation. The Journal of Physical Chemistry B 2012 116: 7040-7047. SCI 2區(qū) Impact factor: 3.603[16] F.-F. Liu Z. Liu S. Bai X.-Y. Dong and Y. Sun*. Exploring the inter-molecular interactions in amyloid-β protofibril with molecular dynamics simulations and molecular mechanics Poisson-Boltzmann surface area free energy calculations. The Journal of Chemical Physics 2012 Apr 14 136 (14):145101. SCI 2區(qū) Impact factor: 3.122[17] S.-H. Wang F.-F. Liu X.-Y. Dong Y. Sun*. Calorimetric and Spectroscopic Studies of the Interactions between Insulin and (-)-Epigallocatechin-3-gallate. Biochemical Engineering Journal 2012 62: 70-78. SCI 2區(qū) Impact factor: 2.467[18] B. Huang F.-F. Liu* X.-Y. Dong Y. Sun*. Molecular Mechanism of the Effects of Salt and pH on the Affinity between Protein A and Human Immunoglobulin G1 Revealed by Molecular Simulations The Journal of Physical Chemistry B 2012 116 424-433. SCI 2區(qū) Impact factor: 3.603[19] Y. Sun* Q.-H. Shi L. Zhang G. Zhao F. -F. Liu: Adsorption and chromatography. In ed. Comprehensive Biotechnology Vol. 2 Chapter 2.47. pp. 665-679. Elsevier 2011.[20] F.-F. Liu X. -Y. Dong L. Z. He A. P. J. Middelberg Y. Sun*: Molecular Insight into Conformational Transition of Amyloid β-Peptide 42 Inhibited by (-)-Epigallocatechin-3-gallate Probed by Molecular Simulations. The Journal of Physical Chemistry B 2011 115 11879-11887. SCI 2區(qū) Impact factor: 3.603[21] B. Huang F.-F. Liu X.-Y. Dong Y. Sun*. Molecular Mechanism of the Affinity Interactions between Protein A and Human Immunoglobulin G1 Revealed by Molecular Simulations. The Journal of Physical Chemistry B 2011 115 4168-4176. SCI 2區(qū) Impact factor: 3.603[22] S.-H. Wang F.-F. Liu X.-Y. Dong Y. Sun*. Thermodynamic Analysis of the Molecular Interactions between Amyloid β-Peptide 42 and (-)-Epigallocatechin-3-gallate. The Journal of Physical Chemistry B 2010 114: 11576-11583. SCI 2區(qū) Impact factor: 3.603[23] F.-F. Liu J. Luo L. Zhang X.-Y. Dong Y. Sun*: Molecular basis for polyol-induced protein stability revealed by molecular dynamics simulations. Journal of Chemical Physics 2010 132: 225103. SCI 2區(qū) Impact factor: 3.122[24] F.-F. Liu J. Luo X.-Y. Dong Y. Sun*: BIOT 146-Molecular dynamics simulation of the inhibition effect of trehalose on the nucleation and elongation of amyloid beta-peptide oligomers. Abstracts of papers of the American Chemical Society Vol: 238 146-BIOT Aug 16 2009. SCI檢索[25] F.-F. Liu J. Luo X.-Y. Dong Y. Sun*: Molecular insight into the inhibition effect of trehalose on the nucleation and elongation of Amyloid β-peptide oligomers. The Journal of Physical Chemistry B 2009 113 (32): 11320-11329. SCI 2區(qū) Impact factor: 3.603[26] Y. Sun* F.-F. Liu Q.-H. Shi: Approaches to high-performance preparative chromatography of proteins Advances in Biochemical Engineering /Biotechnology 2009 113: 217-254. SCI 2區(qū) Impact factor: 2.600[27] F.-F. Liu X.-Y. Dong Y. Sun*: Molecular mechanism for the effects of trehalose on β-hairpin folding revealed by molecular dynamics simulation. Journal of Molecular Graphics & Modelling 2008 27 (4): 421-429. SCI 3區(qū) Impact factor: 2.177[28] F.-F. Liu X.-Y. Dong Y. Sun*: Discovery and design of affinity ligands for protein chromatography. Journal of Biotechnology 2008 136: 497. SCI 2區(qū) Impact factor: 3.037[29] F.-F. Liu X.-Y. Dong T. Wang Y. Sun*: Rational design of peptide ligand for affinity chromatography of tissue-type plasminogen activator by the combination of docking and molecular dynamics simulations. Journal of Chromatography A 2007 1175 (2): 249-258. SCI 2區(qū) Impact factor: 4.467[30] F.-F. Liu T. Wang X.-Y. Dong Y. Sun*: Rational design of affinity peptide ligand by flexible docking simulation. Journal of Chromatography A 2007 1146 (1): 41–50. SCI 2區(qū) Impact factor: 4.467

[教育背景]
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