天津科技大學(xué)生物工程學(xué)院導(dǎo)師：劉逸寒 正文

[導(dǎo)師姓名]
劉逸寒

[所屬院校]
天津科技大學(xué)

[基本信息]
導(dǎo)師姓名：劉逸寒
性別：男
人氣指數(shù)：1769
所屬院校：天津科技大學(xué)
所屬院系：生物工程學(xué)院
職稱：副教授
導(dǎo)師類型：
招生專業(yè)：藥理學(xué)
研究領(lǐng)域：[1]酶制劑開發(fā)與應(yīng)用：酶分子的挖掘與進(jìn)化，酶基因高效表達(dá)系統(tǒng)的構(gòu)建與優(yōu)化，酶蛋白發(fā)酵工藝...

[通訊方式]
辦公電話：022-60601958
電子郵件：lyh@tust.edu.cn
通訊地址：天津經(jīng)濟(jì)技術(shù)開發(fā)區(qū)第十三大街29號天津科技大學(xué)生物工程學(xué)院

[個(gè)人簡述]
代表性專利：[1] 劉逸寒，路福平，樊帥，徐艷靜，胡博，王春霞，王建玲．一種耐酸性高溫α-淀粉酶及其基因工程菌和制備方法，ZL201210246909.6．[2] 劉逸寒，王正祥，路福平，王春霞，王建玲．一種耐高溫α-淀粉酶及其制備方法和應(yīng)用，ZL201510004498.3．[3] 劉逸寒，路福平，薄嘉鑫，王春霞，王建玲．一種細(xì)胞表面展示磷脂酶D酵母全細(xì)胞催化劑催化制備磷脂酰絲氨酸的方法，ZL201110206069.6．[4] 路福平，劉逸寒，張濤，劉曉光，王正祥，王春霞，王建玲．一種磷脂酶A2突變體及其制備方法，ZL201410279966.3．[5] 路福平，劉逸寒，張濤，劉曉光，王正祥，王春霞，王建玲．sn-2位為二十二碳六烯酸的磷脂酰絲氨酸的制備方法，ZL201410279967.8．[6] 路福平，劉逸寒，劉敏堯，劉靚，樊帥，王春霞，王建玲．堿性蛋白酶高產(chǎn)菌株及其所產(chǎn)的堿性蛋白酶，ZL201210417021.4．[7] 路福平，劉逸寒，鄭宏臣，樊帥，王春霞 王建玲．一種耐高溫高堿木聚糖酶及其基因工程菌和制備方法，ZL201210470064.9．[8] 路福平，劉逸寒，藺松，王春霞，王建玲．一種抑制枯草芽孢桿菌谷氨酰胺轉(zhuǎn)胺酶活性的多肽及其篩選方法和應(yīng)用，ZL201210585268.7．[9] 路福平，劉逸寒，鄭宏臣，王春霞，王建玲．一種耐高溫木聚糖酶的高產(chǎn)菌株及利用該菌發(fā)酵產(chǎn)耐高溫木聚糖酶的方法及得到的酶，ZL201110282029.X．[10] 李玉，荊瑋，劉逸寒，劉曉光，王穩(wěn)航，路福平．一種β-葡萄糖苷酶產(chǎn)生菌及利用該菌轉(zhuǎn)化制備京尼平的方法，ZL201110243864.2．[11] 路福平，劉逸寒，劉敏堯，劉靚，薄嘉鑫，王春霞，王建玲．一種低溫堿性蛋白酶及其制備方法，ZL201110220386.3．[12] 路福平，劉逸寒，薄嘉鑫，王春霞，王建玲．高活力磷脂酶D及細(xì)胞表面展示磷脂酶D酵母全細(xì)胞催化劑的制備，ZL201110206481.8．[13] 路福平，郝育杰，劉逸寒，王春霞，肖靜，周浩，蔣彥潔，王珊．一種堿性果膠酶基因工程菌培養(yǎng)條件的優(yōu)化方法，ZL200910070737.X[14] 路福平，杜連祥，劉逸寒，李玉，王建玲，王春霞．高溫耐酸性α-淀粉酶的突變株及其構(gòu)建方法，ZL200810053625.9．[15] 路福平，杜連祥，李濤，史文玉，劉逸寒．采用無機(jī)膜實(shí)現(xiàn)微生物原位分離發(fā)酵的方法，ZL200610015378.4．獲獎(jiǎng)情況[1] 一種耐酸性高溫α-淀粉酶及其基因工程菌和制備方法．2017年度天津市專利獎(jiǎng)金獎(jiǎng)，排名第1．[2] 新型半纖維素酶創(chuàng)制關(guān)鍵技術(shù)的開發(fā)與應(yīng)用．2016年度中國輕工業(yè)聯(lián)合會(huì)科學(xué)技術(shù)進(jìn)步獎(jiǎng)二等獎(jiǎng)，排名第1．[3] 耐高溫α-淀粉酶的定向進(jìn)化及其耐酸突變體在枯草芽孢桿菌中的表達(dá)．2013年度天津市優(yōu)秀博士學(xué)位論文．[4] 重大淀粉酶品的創(chuàng)制綠色制造及其應(yīng)用．2013年度國家技術(shù)發(fā)明獎(jiǎng)二等獎(jiǎng)，排名第6．[5] 一種耐高溫高堿木聚糖酶及其基因工程菌和制備方法．2016年度天津市專利獎(jiǎng)優(yōu)秀獎(jiǎng)，排名第2．[6] 高溫耐酸性α-淀粉酶的突變株及其構(gòu)建方法．2015年度天津市專利獎(jiǎng)優(yōu)秀獎(jiǎng)，排名第3．[7] 果醋釀造的關(guān)鍵技術(shù)及產(chǎn)業(yè)化．2014年度中國商業(yè)聯(lián)合會(huì)全國商業(yè)科技進(jìn)步獎(jiǎng)，排名第5．[8] 高產(chǎn)脂肪酶菌株的選育及發(fā)酵工藝優(yōu)化．2014年度臨沂市科技進(jìn)步獎(jiǎng)二等獎(jiǎng)，排名第2．

[科研工作]
以第一作者先后發(fā)表各類科技論文30余篇，其中SCI收錄22篇EI收錄1篇，獲得國家授權(quán)發(fā)明專利15項(xiàng)。代表性學(xué)術(shù)論文：[1]Liu YH* Li MJ Huang L Gui S Jia LB Zheng D Fu Y Zhang YT Rui JQ Lu FP*. Cloning expression and characterisation of phospholipase B from Saccharomyces cerevisiaeand its application in the synthesis of l-alpha-glyceryl phosphorylcholine and peanut oil degumming[J]. Biotechnology & Biotechnological Equipment doi.org/10.1080/13102818.2018.1455536.[2]Liu YH* Liu H Huang L Gui S Zheng D Jia LB Fu Y Lu FP*. Improvement in thermostability of an alkaline lipase I fromPenicillium cyclopiumby directed evolution[J]. RSC Advances 2017 7:38538-38548.[3] Liu YH* Huang L Jia LB Gui S Fu Y Zheng D Guo W Lu FP*. Improvement of the acid stability of Bacillus licheniformisalpha amylase by site-directed mutagenesis[J]. Process Biochemistry 2017 58:174-180.[4]Liu YH Huang L Guo W Jia LB Fu Y Gui S Lu FP*. Cloning expression and characterization of a thermostable and pH-stable laccase fromKlebsiella pneumoniaeand its application to dye decolorization[J]. Process Biochemistry 2017 53:125-134.[5] Liu YH Huang L Li MJ Liu H Guo W Gui S Niu JL Lu FP*. Characterization of the recombinant porcine pancreas phospholipase A2expressed in Pichia pastorisGS115 and its application to synthesis of 2-DHA-PS[J]. Process Biochemistry 2016 51(10):1472-1478.[6] Huang L1 Liu YH1 Liu XG Ban LT Wang Y Liu MJ Lu FP*. Functional expression of Trametes versicolor thermotolerant laccase variant in Pichia pastoris[J]. Biotechnology & Biotechnological Equipment 2016 30(2):261-269. (Co-first author)[7] Liu YH Huang L Liu WG Guo W Zheng HC WangJL Lu FP*. Studies on properties of the xylanbinding domain and linker sequence of xylanase XynG1-1 from Paenibacillus campinasensisG1-1[J]. Journal of Industrial Microbiology & Biotechnology 2015 42(12):1591-1599.[8]Liu YH Zhang T Qiao J Liu XG Bo JX Wang JL Lu FP*. High-yield phosphatidylserine production via yeast surface display of phospholipase D from Streptomyces chromofuscuson Pichia pastoris[J]. Journal of Agricultural and Food Chemistry 2014 62(23):5354-5360.[9]Liu YH Lin S Zhang XQ Liu XG Wang JL Lu FP*. A novel approach for improving the yield of Bacillus subtilistransglutaminase in heterologous strains[J]. Journal of Industrial Microbiology & Biotechnology 2014 41(8):1227-1235.[10]Liu YH Zhang T Zhang ZM Sun TY Wang JL Lu FP*. Improvement of cold adaptation of Bacillus alcalophilusalkaline protease by directed evolution[J]. Journal of Molecular Catalysis B: Enzymatic 2014 106:117-123.[11]Liu YH Fan S Liu XG Zhang ZM Wang JL Wang ZX* Lu FP*. A highly active alpha amylase from Bacillus licheniformis: directed evolution enzyme characterization and structural analysis[J]. Journal of Microbiology and Biotechnology 2014 24(7):898-904.[12]Liu YH Lin S Liu K Liu XG Zhang XQ Wang HB Lu FP*. High-level expression of the Streptomyces mobaraenseCICC11018 transglutaminase in Corynebacterium glutamicum ATCC13032[J]. Applied Biochemistry and Microbiology 2014 50(5):456-462.[13]Zheng HC1 Liu YH1 Sun MZ Han Y Wang JL Sun JS Lu FP*. Improvement of alkali stability and thermostability of Paenibacillus campinasensisFamily-11 xylanase by directed evolution and site-directed mutagenesis[J]. Journal of Industrial Microbiology & Biotechnology 2014 41(1):153-162. (Co-first author)[14]Wang YP1 Liu YH1 Wang ZX Lu FP*. Influence of promoter and signal peptide on the expression of pullulanase in Bacillus subtilis[J]. Biotechnology Letters 2014 36(9):1783-1789. (Co-first author)[15]Zhang Y1 Liu YH1 Li Y Liu XG Lu FP*. Extracellular expression of pullulanase from Bacillus naganoensisin Escherichia coli[J]. Annals of Microbiology 2013 63(1):289-294. (Co-first author)[16]Liu YH Hu B Xu YJ Bo JX Fan S Wang JL Lu FP*. Improvement of the acid stability of Bacillus licheniformisalpha amylase by error-prone PCR[J]. Journal of Applied Microbiology 2012 113(3):541-549.[17]Liu YH Chen GQ Wang JL Hao YJ Li M Li Y Hu B Lu FP*. Efficient expression of an alkaline pectate lyase gene from Bacillus subtilisand the characterization of the recombinant protein[J]. Biotechnology Letters 2012 34(1):109-115.[18]Zheng HC1 Liu YH1 Liu XG Han Y Wang JL Lu FP*. Overexpression of a Paenibacillus campinasensisxylanase in Bacillus megateriumand its applications to biobleaching of cotton stalk pulp and saccharification of recycled paper sludge[J]. Bioresource Technology 2012 125:182-187. (Co-first author)[19]Zheng HC1 Liu YH1 Liu XG Wang JL Han Y Lu FP*. Isolation purification and characterization of a thermostable Xylanase from a novel Strain Paenibacillus campinasensis G1-1[J]. Journal of Microbiology and Biotechnology 2012 22(7):930-938. (Co-first author)[20]Liu YH Lu FP* Chen GQ Snyder CL Sun J Li Y Wang JL Xiao J. High-level expression purification and characterization of a recombinant medium-temperature α-amylase from Bacillus subtilis[J]. Biotechnology Letters 2010 32(1):119-124.[21]Liu YH Lu FP* Li Y Yin XB Wang Y Gao C. Characterisation of mutagenised acid-resistant alpha-amylase expressed in Bacillus subtilisWB600[J]. Applied microbiology and biotechnology 2008 78(1):85-94. [22]Liu YH Lu FP* Li Y Wang JL Gao C. Acid stabilization of Bacillus licheniformisalpha amylase through introduction of mutations[J]. Applied microbiology and biotechnology 2008 80(5):795-803.[23]Liu YH Xu YJ Fan S BO JX Wang JL Lu FP*. Study on the influencing conditions in the electro-transformation efficiency of Bacillus licheniformisATCC14580[J]. Lecture Notes in Electrical Engineering 2014 251(3):1845-1853.

[教育背景]
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天津科技大學(xué)

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