南方醫(yī)科大學(xué)珠江醫(yī)院導(dǎo)師:劉占國(guó)
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南方醫(yī)科大學(xué)珠江醫(yī)院導(dǎo)師:劉占國(guó) 正文
[導(dǎo)師姓名]劉占國(guó)
[所屬院校]
南方醫(yī)科大學(xué)
[基本信息]
導(dǎo)師姓名:劉占國(guó)
性別:
人氣指數(shù):799
所屬院校:南方醫(yī)科大學(xué)
所屬院系:珠江醫(yī)院
職稱(chēng):副主任醫(yī)師
導(dǎo)師類(lèi)型:碩導(dǎo)
招生專(zhuān)業(yè):急診醫(yī)學(xué)
研究領(lǐng)域:感染免疫
[通訊方式]
電子郵件:zhguoliu@163.com
[個(gè)人簡(jiǎn)述]
長(zhǎng)期從事感染免疫研究,重點(diǎn)關(guān)注膿毒癥發(fā)生、發(fā)展的免疫學(xué)及微生態(tài)改變,探索膿毒癥的發(fā)病機(jī)理及新的治療方法。先后獲得國(guó)家自然基金、廣東省醫(yī)學(xué)科學(xué)技術(shù)研究基金、珠江醫(yī)院中青年人才庫(kù)基金、珠江醫(yī)院院長(zhǎng)基金等多項(xiàng)課題。我們的研究顯示細(xì)胞外組蛋白是導(dǎo)致淋巴細(xì)胞凋亡的重要物質(zhì),并初步探明了組蛋白介導(dǎo)淋巴細(xì)胞凋亡的線粒體通路。
[科研工作]
1.Zhanguo Liu, David M. Cauvi, Erika M. A. Bernardino, Bernardo Lara, Radhames E. Lizardo, Dennis Hawisher, Stephen Bickler, Antonio De Maio*. Isolation and characterization of human urine extracellular vesicles. Cell Stress and Chaperones. 2018:23(5):943-953.2.Gong S, Lan T, Zeng L, Luo H, Yang X, Li N, Chen X, Liu Z, Li R, Win S, Liu S, Zhou H, Schnabl B, Jiang Y*, Kaplowitz N, Chen P*. Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J Hepatol. 2018:69(1):51-59.3. F. Wang, J. Liu, T. Weng, K. Shen, Z. Chen, Y. Yu, Q. Huang, G. Wang, Z. Liu*, S. Jin*.The Inflammation Induced by Lipopolysaccharide can be Mitigated by Short-chain Fatty Acid, Butyrate, through Upregulation of IL-10 in Septic Shock. Scandinavian Journal of Immunology. 2017:85(4):258-263.4. Ping Chang, Bing Mo, David M. Cauvi, Ying Yu, Zhenhui Guo, Jian Zhou, Qiong Huang, Qitao Yan, Guiming Chen, Zhanguo Liu*. Grape seed proanthocyanidin extract protects lymphocytes against histone-induced apoptosis. PeerJ. 2017 5: e3108.5. Ping Chang, Juan Liu, Ying Yu, Shao-Ye Cui, Zhen-Hui Guo, Gui-Ming Chen, Qiong Huang, Zhan-Guo Liu*. Alpha-Lipoic Acid Suppresses Extracellular Histone-Induced Release of the Inflammatory Mediator Tumor Necrosis Factor-a by Macrophages. Cellular Physiology and Biochemistry, 201742(6):2559-25686. Zhan-Guo Liu, Shu-Yuan Ni, Gui-Ming Chen, Jing Cai, Zhen-Hui Guo, Ping Chang, Yu-Sheng Li.Histones-Mediated Lymphocyte Apoptosis during Sepsis Is Dependent on p38 Phosphorylation and Mitochondrial Permeability Transition.PLoS One. 20138(10): e771317. Liu, Z.,Yuan, X.,Luo, Y.,He, Y.,Jiang, Y.,Chen, Z. K.,Sun, E. Evaluating the effects of immunosuppressants on human immunity using cytokine profiles of whole blood. Cytokine.2009 45(2), 141-147
[教育背景]
南方醫(yī)科大學(xué)
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