廣西醫(yī)科大學(xué)國(guó)家生物靶向診治國(guó)際聯(lián)合中心導(dǎo)師：程金科 正文

[導(dǎo)師姓名]
程金科

[所屬院校]
廣西醫(yī)科大學(xué)

[基本信息]
導(dǎo)師姓名：程金科
性別：男
人氣指數(shù)：1115
所屬院校：廣西醫(yī)科大學(xué)
所屬院系：國(guó)家生物靶向診治國(guó)際聯(lián)合中心
職稱：教授
導(dǎo)師類型：碩導(dǎo)/博導(dǎo)
招生專業(yè)：生物化學(xué)與分子生物學(xué)、醫(yī)學(xué)生物化學(xué)與分子生物學(xué)
研究領(lǐng)域：蛋白質(zhì)SUMO修飾與腫瘤；調(diào)控去SUMO化蛋白酶SENP的分子機(jī)制及生物學(xué)功能；蛋白質(zhì)SU...

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[個(gè)人簡(jiǎn)述]
研究員，?博士生導(dǎo)師。上海交通大學(xué)醫(yī)學(xué)院醫(yī)學(xué)科學(xué)研究院細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)研究室主任，基礎(chǔ)醫(yī)學(xué)院分子細(xì)胞生物學(xué)系系主任。1983年本科畢業(yè)于湖南農(nóng)業(yè)大學(xué)獸醫(yī)專業(yè)，1989年獲中國(guó)農(nóng)業(yè)大學(xué)動(dòng)物病理學(xué)專業(yè)碩士學(xué)位，1997年獲中國(guó)醫(yī)學(xué)科學(xué)院/北京協(xié)和醫(yī)學(xué)院腫瘤研究所細(xì)胞生物學(xué)博士學(xué)位。1998－2004年在美國(guó)The?University?of?Texas-M?D?Anderson?Cancer?Center?從事博士后研究；2004－2006年任The?University?of?Texas-M?D?Anderson?Cancer?Center，Instructor；2006－2007年任The?University?of?Texas-M?D?Anderson?Cancer?Center，Assistant?Professor。2007年任上海交通大學(xué)醫(yī)學(xué)院醫(yī)學(xué)科學(xué)研究院研究員至今。

[科研工作]
主要從事蛋白質(zhì)修飾與細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)方面的研究，已獲得國(guó)家自然科學(xué)基金、國(guó)家重大研究計(jì)劃等基金資助。?主要研究方向：?1.?SUMO特異性蛋白酶與腫瘤的發(fā)生與發(fā)展。?2.?SUMO特異性蛋白酶與細(xì)胞分化的調(diào)控。?3.?細(xì)胞周期過程中蛋白質(zhì)的SUMO修飾及調(diào)控機(jī)制。?招生專業(yè)：?細(xì)胞生物學(xué)?代表性論著：?1.?Cheng?J,?Yang?J,?Xia?Y,?Karin?M,?Su?B.?Syndergistic?interaction?of?MEK?kinase?2,?c-Jun?N-terminal?kinase?(JNK)?kinase?2,?and?JNK1?results?in?efficient?and?specific?JNK1?activation.?Molecular?and?Cellular?Biology,?20:2334-2342,?2000.?2.?Yang?J,?Lin?Y,?Guo?Z,?Cheng?J,?Huang?H,?Liao?W,?Chen?J,?Liu?ZG,?Su?B.?Essential?role?of?MEKK3?in?TNFa?induced?NF-kB?activation.?Nature?Immunology?,?2:620-624,?2001.?3.?Su?B,?Cheng?J,?Yang?J,?Guo?Z.?MEKK2?mediates?T?cell?receptor?signals?in?JNK?activation?and?IL-2?gene?expression.?Journal?of?Biological?Chemistry,?276:14784-14790,?2001.?4.?Guo?Z,?Clydesdale?G,?Cheng?J,?Kim?K,?Gan?L,?McConkey?DJ,?Ullrich?SE,?Zhuang?Y,?Su?B.?Disruption?of?MEKK2?in?mice?reveals?an?unexpected?role?for?MEKK2?in?modulating?T-cell?receptor?signal?transduction.?Molecular?and?Cellular?Biology,?22:5761-5768,?2002.?5.?Huang?Q,?Yang?J,?Lin?Y,?Walker?C,?Cheng?J,?Liu?ZG,?Su?B.?Differential?regulation?of?interleukin?1?receptor?and?Toll-like?receptor?signaling?by?MEKK3.?Nature?Immunology,?5:98-103,?2004.?6.?Cheng?J,?Wang?D,?Wang?Z,?Yeh?ETH.?SENP1?Enhances?Androgen?Receptor-Dependent?Transcription?through?Desumoylation?of?Histone?Deacetylase?1.?Molecular?and?Cellular?Biology,?24:6021-6028,?2004.?7.?Kho?Y,?Kim?SC,?Jiang?C,?Barma?D,?Kwon?SW,?Cheng?J,?Jaunbergs?J,?Weinbaum?C,?Tamanoi?F,?Falck?J,?Zhao?Y.?A?tagging-via-substrate?technology?for?detection?and?proteomics?of?farnesylated?proteins.?PNAS,?101:12479-12484,?2004.?8.?Cheng?J,?Zhang?D,?Kim?K,?Zhao?Y,?Su?B.?Mip1,?an?MEKK2-interacting?protein,?controls?MEKK2?dimerization?and?activation.?Molecular?and?Cellular?Biology,?25:5955-5964,?2005.?9.?Veltman?IM,?Vreede?LA,?Cheng?J,?Looijenga?LH,?Janssen?B,?Schoenmakers?EF,?Yeh?ETH,?van?Kessel?AG.?Fusion?of?the?SUMO/Sentrin-specific?protease?1?gene?SENP1?and?the?embryonic?polarity-related?mesoderm?development?gene?MESDC2?in?a?patient?with?an?infantile?teratoma?and?a?constitutional?t(1215)(q13q25).?Human?Molecular?Genetics,?14:1955-1963,?2005.?10.?Cheng?J,?Pekins?ND,?Yeh?ETH.?Differential?regulation?of?c-Jun-dependent?transcription?by?SUMO-specific?proteases.?Journal?of?Biological?Chemistry,?280:14492-14498,?2005.?11.?Cheng?J,?Yu?L,?Zhang?D,?Huang?Q,?Spencer?D,?Su?B.?Dimerization?through?the?catalytic?domain?is?essential?for?MEKK2?activation.?Journal?of?Biological?Chemistry,?280:?13477-13482,?2005.?12.?Cheng?J,?Bawa?T,?Lee?P,?Gong?L,?Yeh?ET.?Role?of?desumoylation?in?the?development?of?prostate?cancer.?Neoplasia,?8:667-676,?2006.?13.?Gao?F,?Cheng?J,?Shi?T,?and?Yeh?ET.?NEDDylation?of?a?Breast?Cancer–asociated?Protein?Recruits?a?Class?III?Histone?Deacetylase?that?Represses?NF-?B-dependent?Transcription.?Nature?Cell?Biology,?8:1171-1177,?2006.?14.?Cheng?J,?Kang?X,?Zhang?S?and?Yeh?ET.?SUMO-specific?protease?1?is?essential?for?stabilization?of?HIF1??during?hypoxia.?Cell,?131:584-595,?2007.?15.?Bawa-Khalfe?T,?Cheng?J,?Wang?Z?and?Yeh?ET.?Induction?of?the?sumo-specific?protease?1?transcription?by?the?androgen?receptor?in?prostate?cancer?cells.?Journal?of?Biological?Chemistry,?282:37341-37349,?2007.??代表性論著。

[教育背景]
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