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大連醫(yī)科大學基礎(chǔ)醫(yī)學院導師：燕秋

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大連醫(yī)科大學基礎(chǔ)醫(yī)學院導師：燕秋正文

[導師姓名]
燕秋

[所屬院校]
大連醫(yī)科大學

[基本信息]
導師姓名：燕秋
性別：
人氣指數(shù)：858
所屬院校：大連醫(yī)科大學
所屬院系：基礎(chǔ)醫(yī)學院
職稱：教授
導師類型：碩導
招生專業(yè)：
研究領(lǐng)域：糖生物學

[通訊方式]
辦公電話：86110308
電子郵件：yanqiu63@126.com

[個人簡述]
燕秋,博士，教授，博士、碩士生導師?，F(xiàn)任大連醫(yī)科大學基礎(chǔ)醫(yī)學院生物化學與分子生物學教研室主任。從事分子生物學及糖復合物結(jié)構(gòu)和功能的研究多年?，F(xiàn)為遼寧省重點學科主任、遼寧省糖生物學與糖工程重點實驗室主任。主持自然基金多項，獲遼寧省科學進步獎兩項。通過省級科技成果鑒定一項。被評為大連市優(yōu)秀發(fā)明家, 遼寧省 “百千萬人才工程” 千層次、遼寧省教學名師等榮譽稱號。

[科研工作]
承擔的國家級項目：（近5年）1.國家自然科學基金生殖內(nèi)分泌激素對多囊卵巢綜合征（PCOS）蛋白質(zhì)糖基化的調(diào)控及致病機制的研究 2017.01-2020.12 主持；2.國家自然科學基金胚胎發(fā)育和著床過程中O-巖藻糖化的特征及功能研究2013.01-2016.12 主持；3.國家自然科學基金子宮內(nèi)膜LeY/sLeX糖蛋白的分析及其在胚胎著床中作用的研究2011.01-2013.12 主持；
代表性論文（近5年）：1.Aziz F, Gao W, Yan Q. Fucosyltransferase-4 and Oligosaccharide Lewis Y Antigen as potentially Correlative Biomarkers of Helicobacter pylori CagA Associated Gastric Cancer. Pathol Oncol Res. 2016 Oct 18.2.Zheng Q, Dai K, Cui X, Yu M, Yang X, Yan B, Liu S, Yan Q. Leukemia inhibitory factor promote trophoblast invasion via urokinase-type plasminogen activator receptor in preeclampsia. Biomed Pharmacother. 2016 May80:102-8.3.Tian L, Shen D, Li X, Shan X, Wang X, Yan Q, Liu J. Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down-regulating FUT4.Oncotarget. 2016 Jan 127(2):1619-32.4.Aziz F, Wang X, Liu J, Yan Q. Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions. Toxicol In Vitro. 2016 Mar31:158-66.5.Gao J, Liu X, Yang F, Liu T, Yan Q, Yang X. By inhibiting Ras/Raf/ERK and MMP-9, knockdown of EpCAM inhibits breast cancer cell growth and metastasis.Oncotarget. 2015 Sep 296(29):27187-98.6.Shan X, Tian LL, Zhang YM, Wang XQ, Yan Q, Liu JW. Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death.Int J Oncol. 2015 Aug47(2):701-9.7.Gao W, Liang JX, Liu S, Liu C, Liu XF, Wang XQ, Yan Q. Oxidative damage of DNA induced by X-irradiation decreases the uterine endometrial receptivity which involves mitochondrial and lysosomal dysfunction. Int J Clin Exp Med. 2015 Mar 158(3):3401-10.8.Gao W, Liang JX, Yan Q. Exposure to radiation therapy is associated with female reproductive health among childhood cancer survivors: a meta-analysis study. J Assist Reprod Genet. 2015 Aug32(8):1179-869.Aziz F, Yang X, Wen Q, Yan Q. A method for establishing human primary gastric epithelial cell culture from fresh surgical gastric tissues. Mol Med Rep. 2015 Aug12(2):2939-4410.Zhang YM, Zhang YY, Bulbul A, Shan X, Wang XQ, Yan Q. Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta-catenin signaling pathway.FEBS Lett. 2015 May 8589(11):1225-33.11.Yan X, Lin Y, Liu S, Aziz F, Yan Q.Fucosyltransferase IV (FUT4) as an effective biomarker for the diagnosis of breast cancer.Biomed Pharmacother. 2015 Mar70:299-304.12.Shan X, Aziz F, Tian LL, Wang XQ, Yan Q, Liu JW.Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/LeY expression.Int J Oncol. 2015 Apr46(4):1667-76.13.Hongyan L, Shaoming T, Qiu Y.Correlation between FUT4 expression and its promoter methylation in HaCaT cells.Yi Chuan. 2015 Jan37(1):48-54.14.Aziz F, Yang X, Wang X, Yan Q.Anti-LeY antibody enhances therapeutic efficacy of celecoxib against gastric cancer by downregulation of MAPKs/COX-2 signaling pathway: correlation with clinical study.J Cancer Res Clin Oncol. 2015 Jul141(7):1221-3515.Shan X, Fu YS, Aziz F, Wang XQ, Yan Q, Liu JW. Ginsenoside Rg3 inhibits melanoma cell proliferation through down-regulation of histone deacetylase 3 (HDAC3) and increase of p53 acetylation. PLoS One. 2014 Dec 189(12):e115401.16.Liu S, Wang J, Qin HM, Yan XM, Yang XS, Liu C, Yan Q. LIF upregulates poFUT1 expression and promotes trophoblast cell migration and invasion at the fetal-maternal interface. Cell Death Dis. 2014 Aug 285:e1396.(IF:5.177)17.Liu S, Yang X, Wang J, Wei J, Zhang D, Wang X, Yan Q. Differential expression of LeY and fucosyltransferase IV correlates with the receptivity of RL95-2 and HEC-1A human uterine epithelial cells. Cell Biol Int. 2012 May 136(5):469-74. (IF:1.64)18.Liu S, Yang X, Liu Y, Wang X, Yan Q. sLeX/L-selectin mediates adhesion in vitro implantation model. Mol Cell Biochem. 2011 Apr350(1-2):185-92. (IF:2.33)19.Gao J, Yan Q, Liu S, Yang X.Knockdown of EpCAM enhances the chemosensitivity of breast cancer cells to 5-fluorouracil by downregulating the antiapoptotic factor Bcl-2.PLoS One. 2014 Jul 149(7):e102590. (IF:3.534)20.Gao J, Yan Q, Wang J, Liu S, Yang X. Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by AP1-Dependent EpCAM Expression in MCF-7 Cells.J Cell Physiol. 2014 Sep 9. (IF:3.874)21.Wang J, Liu S, Qin HM, Zhao Y, Wang XQ, Yan Q. Pregnancy-associated plasma protein A up-regulated by progesterone promotes adhesion and proliferation of trophoblastic cells. Int J Clin Exp Pathol. 2014 Mar 157(4):1427-37. (IF:1.783)22.Yang X, Wang J, Liu S, Yan Q. HSF1 and Sp1 regulate FUT4 gene expression and cell proliferation in breast cancer cells. J Cell Biochem. 2014 Jan115(1):168-78. (IF:3.368)23.Yang X, Liu S, Yan Q.Role of fucosyltransferase IV in epithelial-mesenchymal transition in breast cancer cells. Cell Death Dis. 2013 Jul 254:e735. (IF:5.177)24.Yang XS, Liu SA, Liu JW, Yan Q. Fucosyltransferase IV enhances expression of MMP-12 stimulated by EGF via the ERK1/2, p38 and NF-κB pathways in A431 cells. Asian Pac J Cancer Prev. 201213(4):1657-62. (IF:1.5)25.Wei X, Liu S, Wang X, Yan Q. CD82 expression alters with human endometrial cycles and affects the uterine endometrial receptivity in vitro. Exp Biol Med (Maywood). 2012 Mar 1237(3):254-62. (IF:2.8)26.Yang XS, Liu S, Liu YJ, Liu JW, Liu TJ, Wang XQ, Yan Q. Overexpression of fucosyltransferase IV promotes A431 cell proliferation through activating MAPK and PI3K/Akt signaling pathways. J Cell Physiol. 2010 Nov225(2):612-9. (IF:3.986)

[教育背景]
1995年9月——1998年7月理學博士大連醫(yī)科大學/瑞典哥德堡大學；
1987年9月——1990年7月理學碩士白求恩醫(yī)科大學；
1981年9月——1987年7月醫(yī)學學士白求恩醫(yī)科大學。

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